Worth the cost? A closer look at the da Vinci robot’s impact on prostate cancer surgery (2022)

Worth the cost? A closer look at the da Vinci robot’s impact on prostate cancer surgery (1)

Loved by surgeons and patients alike for its ease of use and faster recovery times, the da Vinci surgical robot is less invasive than conventional procedures, and lacks the awkwardness of laparoscopic (keyhole) surgery. But the robot’s US$2-million price tag and negligible effect on cancer outcomes is sparking concern that it’s crowding out more affordable treatments.

There are more than 5,500 da Vinci robots globally, manufactured by California-based tech giant, Intuitive. The system is used in a range of surgical procedures, but its biggest impact has been in urology, where it has a market monopoly on robot-assisted radical prostatectomies (RARP), the removal of the prostate and surrounding tissues to treat localized cancer. Uptake in the United States, Europe, Australia, China and Japan for performing this procedure has been rapid. In 2003, less than 1% of surgeons in the US performed a RARP in preference to open or laparoscopic surgery. By 2014, RARP accounted for up to 90% of radical prostatectomies across the country. When it comes to prostate cancer surgery in the United States, says Benjamin Davies, surgeon and professor of urology at the University of Pittsburgh, “the die is cast; there is only robotic surgery”.

Nature Index Cancer 2020

After lung cancer, prostate cancer is the second most common cancer in men worldwide. It affects the walnut-sized prostate gland, which sits up against the urethra, between the rectum and bladder, and secretes prostate fluid, a component of semen. The prostate’s proximity to the blood vessels, muscles and a fragile web of nerve bundles that control erectile and bladder function, demands extreme surgical precision in its removal, a procedure that is generally recommended if the disease has not yet spread. Whereas an open patient needs to be cut from naval to pubic bone in order to access the prostate, a robot-assisted procedure requires a few small abdominal incisions.

Known as a master–slave system, the da Vinci comprises three main components. The tower (or ‘slave’) wields three arms equipped with instruments such as forceps, hooks and needle-drivers, and a fourth holds cameras capable of 15 times magnification. The console (‘master’) is where the surgeon sits, a few metres from the patient, remotely operating the robot arms while watching through a 3D stereoscopic monitor. A separate cart contains image-processing equipment.

(Video) Robotic surgery for prostate cancer

Surgeons prefer to use the da Vinci robot because it offers improved visualization and hand and wrist flexibility, and they can be seated throughout the 2- to 4-hour procedure. “We can see the anatomy of the prostate like we have never seen it before,” says Freddie Hamdy, Nuffield professor of surgery and urology at the University of Oxford, UK, which is ranked 26th in the Nature Index for cancer research output.

Rise of the robot

1982: Patrick Walsh from Johns Hopkins University performs the first nerve-sparing radical prostatectomy, making it possible to preserve sexual function and urinary continence in some patients.

1995: Intuitive, da Vinci’s manufacturer, is founded by surgeon Frederic Moll, engineer Robert Younge, and venture capitalist John Freund.

1998: The first commercial sale of a da Vinci robotic system is made to the Leipzig Heart Center in Germany.

2000: The da Vinci is the first robotic system to gain FDA approval for general laparoscopic surgery.

(Video) Robotic Surgery for Prostate Cancer at Sarasota Memorial

2001: An account of the first robotically assisted radical prostatectomy, which was performed using a da Vinci system, is published in the BJU International by J. Binder and W. Kramer at the Johann Wolfgang Goethe University in Germany (Binder, J. & Kramer, W. BJU Int. 87, 408–410; 2001).

2009: 86% of prostate cancer surgeries in the United State are robot-assisted operations.

2019: Intuitive’s stock price grows 66% from US$312 in 2017 to $520 in 2019. Its total revenues grow from $3.7 billion in 2018 to $4.5 billion in 2019 (preliminary).

Cancer outcomes equal

Whether these improvements translate to better long-term outcomes for the patient, however, remains unclear. Ruban Thanigasalam, associate professor of robotic surgery at the University of Sydney and clinical lead in prostate cancer research at the Institute of Academic Surgery in Australia, is conducting a trial comparing open and robotic surgery. The preliminary results support what has been widely accepted by surgeons for years: robotic-surgery patients experience reduced blood loss, less pain and shorter recovery time, but the longer-term outcomes are equivalent.

“Anecdotally, we find that recovery of continence is earlier in the robotic group, but after 12 months, there is no major difference between the two for urinary control and sexual function,” says Thanigasalam. For the cancer itself, he adds, the outcomes are the same.

“Several international studies looking at tens of thousands of patients have all shown that there is absolutely no difference in cancer outcomes between robotic and open surgery.”

Worth the cost? A closer look at the da Vinci robot’s impact on prostate cancer surgery (3)

(Video) Cleveland Clinic shows progress in prostate cancer removal with improved robotic surgery

Thanigasalam stresses that the outcomes of robotic surgery remain dependent on the surgeon’s skills, a sentiment echoed by Davies: “It’s always the surgeon’s hands, not the technology we use.”

Even da Vinci’s proponents acknowledge the temptation to overplay its ability. “We all love a good robot,” says Richard Sullivan, professor of cancer and global health at King’s College London and director of the Institute of Cancer Policy in the United Kingdom. “Human beings, particularly surgeons, are incredibly neophilic. We love this sort of thing, it gives us authority. And the patient will think that, because you’ve got all of this fancy kit, you must have better outcomes. But that’s not true, the robot is not an indicator of quality.”

Worth the cost? A closer look at the da Vinci robot’s impact on prostate cancer surgery (4)

Accessibility gap

According to a 2017 report by the Royal Australasian College of Surgeons and Australian health insurance provider, Medibank, the cost of a prostate cancer procedure varied nationwide from Aus$14,553 to Aus$55,928 (US$9,165 to US$35,222). The use of robotics, the report states, “can substantially increase the cost”.

Despite questions over value for money, business is booming. In 2018, the global surgical robots market was worth US$6.8 billion, and it’s predicted to hit $17 billion by 2025. In response to the surge in robotic surgery, the US Food and Drug Administration (FDA) urged patients and health-care providers to exercise caution last year, particularly with regards to breast and cervical cancer, citing a lack of long-term evidence. “The problem is, once it becomes adopted, it can be very difficult to pedal it back,” says Hamdy.

(Video) What is a robotic prostatectomy?

A “massive inequality gap” is opening between hospitals that can afford the robot, and those that can’t, says Sullivan. “In many countries, we’re fighting for patients because of choice and competition. If I’ve got a robot, I can sell that fact to patients, and they’ll come to me rather than the centre down the road.”

A 2019 paper co-authored by Sullivan for the World Health Organization found that competition between hospitals with and without surgical robots contributed to the closure of 25% of radical prostatectomy centres in the English National Health Service. This focus on “expensive medicines for wealthy patients in wealthy countries”, the paper states, is putting low-income groups at a disadvantage by crowding out spending on the development of preventative measures (R. Sullivan and A. Aggarwal in Reducing Social Inequalities in Cancer: Evidence and Priorities for Research, IARC Monograph, 2019).

Worth the cost? A closer look at the da Vinci robot’s impact on prostate cancer surgery (5)

A stark divide also exists between high-income and low- and middle-income countries, which makes it difficult to treat patients across borders, says Sullivan. “Most of our juniors [in the UK] have been trained in minimally invasive and robotics surgery,” he says. “They’re saying, ‘If I want to work somewhere like Zambia or India, I’m screwed if I’ve only done minimally invasive or robotics.’ Outside the high-income settings, these services aren’t available.”

Competition could drive the price of the da Vinci robot down, such as from UK-based CMR Surgical, which has raised $240 million since 2016 for its Versius robot, and Verb Surgical, a partnership between Johnson & Johnson and Alphabet.

Improved screening could see fewer men undergoing surgery in the first place. There is evidence that the benefits of the prostate-specific antigen (PSA) blood test, which, along with a digital rectal examination, is the most common way to screen for prostate cancer, may not outweigh the potential harm of misdiagnosis leading to unnecessary surgery or radiation. Researchers from the Queen Mary University of London and University of East Anglia, UK, are developing blood and urine tests to be used in conjunction with the PSA.

(Video) Robotic Prostate Surgery vs. Standard Prostate Surgery | Ask a Prostate Expert, Mark Scholz, MD

This article is part of Nature Index Cancer 2020, an editorially independent supplement. Advertisers have no influence over the content.

FAQs

Who is the best robotic prostate surgeon? ›

Dr. Razdan is recognized as one of the highest volume and most experienced robotic prostate surgeons in the world. He has performed over 9,000 Robotic Surgeries and is considered by many to be one of the best in the world.

How successful is robotic prostate surgery? ›

The positive margin rate was 9.4% for all patients; i.e. 2.5% for T2 tumours, 23% for T3a and 53% for T4. The overall biochemical recurrence free (PSA level<0.1 ng/mL) survival was 95% at mean follow-up of 9.7 months. There was complete continence at 3 and 6 months in 89% and 95% of patients, respectively.

Is robotic surgery Best for prostate cancer? ›

Outcomes from use of a robot to assist surgeons in removal of a cancerous prostate are at least as good, if not better, than the other two techniques used for a radical prostatectomy — open or laparoscopic surgery — according to a large meta analysis led by researchers at NewYork-Presbyterian/Weill Cornell.

What is the success rate of the da Vinci surgery? ›

Data analysis retrieved from the da Vinci console reported on a total of 807 procedures since 2003. Only 4 cases (0.4%) were reported from the Intuitive Surgical database to result in either an aborted or a converted case, which compares favorably with our results.

What is the life expectancy after prostate surgery? ›

Based on the natural history of localized prostate cancer, the life expectancy (LE) of men treated with either radical prostatectomy (RP) or definitive external-beam radiotherapy (EBRT) should exceed 10 years.

What is the cost of robotic prostate surgery? ›

Results: Mean hospital cost per robot-assisted radical prostatectomy was $11,878 (95% CI $11,804-$11,952). Mean cost was $2,837 (95% CI $2,805-$2,869) in the low cost group vs $25,906 (95% CI $24,702-$25,490) in the high cost group.

How long does da Vinci prostate surgery take? ›

Typically, the surgery lasts 2-3 hours in the operating room. Patients awaken in the recovery room, and discomfort is usually mild. The next morning, patients are ambulating, eating regular food, and are discharged to home with a catheter in their bladder to allow healing.

Is robotic prostatectomy better than open? ›

, most prostatectomies are performed robotically. But it isn't the best choice. There is no qual- ity evidence that robotic procedures deliver better outcomes than open ones.

How long is hospital stay after robotic prostatectomy? ›

Prostatectomy patients typically spend one night in the hospital and are usually discharged as soon as their laboratory tests are acceptable, pain is controlled and they are able to retain liquids. Patients are discharged with special catheter, which is removed during an outpatient visit 5-7 days after the operation.

What are the cons of robotic surgery? ›

Disadvantages of robot-assisted surgery are:
  • Only available in centers that can afford the technology and have specially trained surgeons.
  • Your surgeon may need to convert to an open procedure with larger incisions if there are complications. ...
  • Risk of nerve damage and compression.
Dec 15, 2021

How much does a Davinci cost? ›

The cost of the da Vinci robot was obtained from Intuitive Surgical. This analysis utilized the $1.5 million da Vinci-S robot. The cost of the robot was amortized over 5 years; thus, the robot costs $300,000 per year and the service contract is $112,000 per year.

How much does a da Vinci XI robot cost? ›

Salvatore Brogna, senior vice president for product development at Intuitive, says the new robot will be available immediately and cost between $1.85 million and $2.3 million. The da Vinci Xi is being marketed to surgeons as a solution for more complex surgeries.

What are some disadvantages of using the da Vinci robot? ›

da Vinci Surgical System Complications
  • Longer operation and anesthesia times.
  • Device malfunction or failure (leading to serious injury or requiring an alternate surgical approach)
  • Increase in complications can result from switching to another surgical approach.
  • Bleeding (sometimes in large amounts requiring transfusion)

What is the fail rate of robotic surgery? ›

A study including 725 cases of robotic radical prostatectomy reported that robotic device failure resulted in case conversion, procedure abortion, or surgeon handicap in none, 0.5% and 0.4% of procedures, respectively [4].

Do patients prefer robotic surgery? ›

Over 20% of respondents indicated that the robot had some degree of autonomy during surgery. Most respondents (72%) indicated that RS was safer, faster, and less painful or offered better results, but when asked if they would choose to have RS, 55% would prefer to have conventional minimally invasive surgery.

Who is not a candidate for robotic prostate surgery? ›

Patients with known metastatic or recurrent prostate cancer are not candidates for robotic prostatectomy. Although patients with very large prostate glands (e.g. > 100 grams) can undergo robotic prostatectomy, operative times are generally longer than in patients with smaller prostate gland sizes.

Can you still have an erection if your prostate is removed? ›

Most men who have normal sexual function and receive treatment for early prostate cancer regain erectile function and can have satisfying sex lives after robotic prostatectomy.

What is the most common problem after prostatectomy? ›

Stress incontinence is the most common type after prostate surgery. It's usually caused by problems with the valve that keeps urine in the bladder (the bladder sphincter). Prostate cancer treatments can damage this valve or the nerves that keep the valve working.

Who has done the most robotic prostatectomies? ›

The World's Most Experienced Robotic Surgeon

Vipul Patel serves as the Medical Director of the Global Robotics Institute. He has personally performed the most robotic prostatectomies in the world and has currently performed over 16,000 procedures.

Who is the number one urologist in the United States? ›

Mayo Clinic in Rochester, Minnesota, is ranked No. 1 for urology in the U.S. News & World Report Best Hospitals rankings.

What state has the best urologists? ›

Wisconsin is the best state for urologists, where the median salary is $214,787. Our research put North Dakota at no. 1 on the list of best paying states for urologists. Wisconsin, Minnesota, and Nebraska also ranked high on our list.
...
1. Wisconsin.
Total Urologist Jobs:40
Highest 10 Percent Earn:$290,000
3 more rows
Apr 6, 2021

What type of surgeon removes prostate? ›

This is the most common surgical approach used by urologists (doctors who specialize in diseases and surgery of the urinary tract). If there's reason to believe the cancer has spread to the lymph nodes, the doctor will remove lymph nodes from around the prostate gland, in addition to the prostate gland.

Is it better to have prostate removed or radiation? ›

Both radiation and surgery are equally effective treatments to cure prostate cancer." The choice of which treatment is best is up to individual patients and their care teams, Dr. King says. "Make sure you talk with a surgeon and a radiation oncologist before you make your decision.

What is the latest prostate surgery technique? ›

Holmium laser prostate surgery is a minimally invasive treatment for an enlarged prostate. Also called holmium laser enucleation of the prostate (HoLEP), the procedure uses a laser to remove tissue that is blocking urine flow through the prostate.

How many hours does prostate surgery take? ›

A prostatectomy takes about two hours. You will be under general anesthesia, so you'll be completely asleep. During the surgery, your doctor will: Make a small incision to gain access to your prostate.

Videos

1. Robot Prostate Cancer Surgery Step by Step High Definition Video by an Experienced Surgeon
(Naveen Kella)
2. Prostate Cancer: daVinci Robotic Prostatectomy
(UAB Medicine)
3. Robotic assisted cardiac surgery - is this the future?
(NB Heart Centre CV Rounds)
4. Robotic Assisted Laparoscopic Radical Prostatectomy | Brigham and Women's Hospital
(Brigham And Women's Hospital)
5. Medical Robotics: From Surgery to Rehabilitation with Allison Okamura
(Stanford Alumni)
6. CSF2021 How da Vinci Surgery Benefits our Colorectal Program
(Minogue Medical)

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